Drinking alcohol changes the shape of “go” neurons, a part of the brain that makes you want to act—in this case, pour another drink—new research shows. And binge drinking over time makes it easier for these neurons, called D1, to activate, which causes you to crave more booze.
“If these neurons are excited, you will want to drink alcohol,” says Jun Wang, an assistant professor in the neuroscience and experimental therapeutics at the Texas A&M College of Medicine. “You’ll have a craving.”
That is to say, when neurons with D1 receptors are activated, they compel you to perform an action. This then creates a cycle, where drinking causes easier activation, and activation causes more drinking.
Wang and colleagues determined by studying animals that alcohol actually changes the physical structure of medium spiny neurons, the main type of cell in the striatum. These neurons can be thought of like a tree, with many branches, and many small protrusions, or spines, coming off of them.
They each have one of two types of dopamine receptors, D1 or D2, and so can be thought of as either D1 or D2 neurons.
D1 neurons are informally called part of a “go” pathway in the brain, while D2 neurons are in the “no-go” pathway. In other words, when D2 neurons are activated, they discourage action—telling you to wait, to stop, to do nothing.
Although it is well known that the neurotransmitter dopamine is involved in addiction, this study goes further, showing that the dopamine D1 receptor also plays an important role in addiction.
HOW ALCOHOL ALTERS THE BRAIN
These changes in activation of D1 neurons might be related to the physical changes happening at the sub-cellular level in brains that have been exposed to alcohol. They have longer branching and more of the mature, mushroom-shaped spines—the type that stores long-term memories—than their abstaining counterparts.
Conversely, the placebo group in the study—the animals not exposed to alcohol—tended to have more of the immature versions of the mushroom-shaped spines in D1 neurons of their brains. The total number of spines didn’t change in the two groups, but the ratio between mature and immature was dramatically different between the alcohol group and the placebo group. This has important implications for memory and learning in drug addiction.
“When you drink alcohol, long-term memory is enhanced, in a way,” Wang says. “But this memory process is not useful—in fact, it underlies addiction since it affects the ‘go’ neurons.”
Because there was no difference in the number of each type of spine in the D2 (no-go) neurons of alcohol-consuming and control models, the researchers realized there was a specific relationship between D1 neurons and alcohol consumption.
“We’re now able to study the brain at the neuron-specific and even spine-specific level,” says Wang, lead author of a paper published in the Journal of Neuroscience.
How do you determine which neuron, which type of neurons or which group of neurons is responsible for a specific disease? That’s what the next part of the study tried to answer.
The alcohol-consuming animal models with the increased mature spines in D1 neurons also showed an increased preference to drink large quantities of alcohol when given the choice.
“Even though they’re small, D1 receptors are essential for alcohol consumption,” Wang says.
Perhaps most excitingly, when those same animal models were given a drug to at least partially block the D1 receptor, they showed much-reduced desire to drink alcohol. However, a drug that inhibited the D2 dopamine receptors had no effect.
“If we suppress this activity, we’re able to suppress alcohol consumption,” Wang says. “This is the major finding. Perhaps in the future, researchers can use these findings to develop a specific treatment targeting these neurons.”
“My ultimate goal is to understand how the addicted brain works,” Wang says, “and once we do, one day, we’ll be able to suppress the craving for another round of drinks and ultimately, stop the cycle of alcoholism.”
A grant from the National Institute on Alcohol Abuse and Alcoholism funded the study, which researchers from the University of California, San Francisco, coauthored.